Classic granular cell tumors (GCTs) stain strongly and uniformly positive for S100 protein and are believed to show Schwann cell derivation. Polypoid cutaneous tumors composed of cells with large nuclei and abundant granular cytoplasm that do not stain for S100 protein or show apparent Schwannian differentiation have been reported by several groups under names including "primitive polypoid granular cell tumors," "dermal nonneural granular cell tumor," and "primitive nonneural granular cell tumors of skin." We report a polypoid tumor composed of S100-negative epithelioid cells with abundant eosinophilic granular cytoplasm that meets diagnostic criteria for (primitive polypoid dermal) nonneural GCT but also meets criteria for a granular cell variant of epithelioid cell histiocytoma. We have identified a single previous report of a similar lesion. We report the immunohistochemical characteristics of these lesions and address how they are best classified.

Abstract:Studies have established ultraviolet (UV) exposure with increased melanoma skin cancer risk. The combination of UV exposure, high altitude, and reflection of UV rays on the snow may create a particularly relevant and high-risk population amongst those who participate in snow sports. The current study aims to determine the effectiveness of a UV-photography and personalized counseling-based intervention to improve sun protection awareness on the snow sport enthusiast population. Participants were recruited at the 2013 SnowSports Industries American (SIA) Snow Show in Denver to complete a 14 question pre-survey assessing sun-safety awareness followed by a Faraghan Medical Elise Digital UV Camera photograph of their face and counseling regarding individual results. Participants were contacted one to two months later by telephone to complete a ten question post-survey. Forty-one percent of participants (46/112) completed both pre-and post-surveys. The UV photography based intervention influenced the opinions and behaviors of sun protection in 78% of male and 62% of female participants with sunscreen use identified as the most frequently modified behavior (53%). While valid barriers to UV photography use include a current lack of reimbursement and lack of public knowledge of its utility, our study indicates the potential impact of UV photography-based interventions among high-risk populations who avidly participate in snow sports.