A triflic anhydride mediated one-pot tandem reaction involving a Pictet–Spengler-like annulation step has been developed for the synthesis of 3,4-dihydroquinazolines.

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and a light engine, which enable real-time spectral display of tissue perfusion and blood flow on-demand. Safety was measured by adverse event occurrence to patient, surgeon, or technology; feasibility by efficiency, accuracy, and display quality; usability by the human factor testing on Likert scale (0-5), per FDA guidelines.RESULTS: Eighteen consecutive colorectal (n¼8) and bariatric (n¼10) patients were enrolled. No adverse event was observed. The latency of real-time display (<150 msec) was imperceptible. Perfusion by LSCI was concordant with time sensitive indocyanine green (ICG) (100%) only immediately after ICG injection 2 minutes). In user evaluation (n¼10), display quality was 3.95 AE 1.15; ease of setup: 4.09 AE 0.86; form-factor: 3.91 AE 1.13; weight: 4.04 AE 1.17. CONCLUSION:In this FIH trial, real-time detection/display of tissue perfusion and blood flow using ActivSight is safe, easy-touse as measured by human factor testing, and provides real-time accurate display of tissue perfusion without latency and fluorophore.