This qualitative article explores the potential role of health care social enterprises (SEs) as disruptive innovators in improving the availability, accessibility, and affordability of health care delivery. It focuses on the context and mechanisms that enable SEs to produce positive health outcomes. Findings from an in-depth interview with the representatives of SEs and stakeholders in Malaysia reveal that strategies to balance the elements of social and enterprise (business) are the key for SEs to sustain in the market. This is supported with several inclusive business models such as inclusive employment model, cross-subsidization, and flexible fees payment mechanism, as well as collaborative engagement with multiple stakeholders, expert domains, and social workers. This article also highlights several main challenges in health care SEs, namely financial sustainability, impact measurement, scaling up of project, and political influence. This article ends with a few salient policies that focus on nurturing and strengthening health care SEs.