This review is devoted to the analysis of the published results of studies conducted in Africa, which studied the clinical and epidemiological features of epilepsy disease in the countries of the African continent. Continental geographic subregions have been identified where the prevalence of epilepsy is particularly high. The relationship between the incidence of epilepsy and the presence of endemic neuroinfections is described. It is concluded that the strengthening of measures aimed at the prevention of infections of the central nervous system can be one of the most effective ways to reduce the morbidity and mortality from epilepsy in Africa