Five out of twelve 13- to 15-month-old children, attending the same class of a creche in Forli (Italy), presented infantile papular acrodermatitis (Gianotti-Crosti syndrome), associated with lymphocytosis and evidence for a recent Epstein-Barr virus infection. This cluster may be due to two facts: (1) the long and close contacts among the patients and (2) the concurrent immunization with a combined diphtheria-tetanus-pertussis-polyomyelitis vaccine from 2 to 6 weeks previously.

We report the case of a 3-year-old boy with classical chronic bullous disease of childhood (CBDC) arising after recent Epstein-Barr virus seroconversion following infectious mononucleosis. The patient also had small red cells and decreased levels of circulating IgA. He received combined treatment with dapsone and prednisone with good results. Our report is the first of CBDC preceded by Epstein-Barr virus seroconversion. The virus may have had an initial immunopathogenic role in the genesis of the bullous eruption.

Ohjectives To investigate .skin disorders related to Epstein Barr Virus (EBV) seroconversion and review the literature on this topic.Patients and methods 77 patients admitted to three Departments (Dermatology, Infectious Diseases, Pediatrics) presented clinical and laboratory (Enzyme Linked Immunosorbent Assay) findings of EBV primary infection. 54/77 (70.1%), ranging in age from 9 months to 41 years and suffering from various skin disorders, were selected.Results 8/54 presented Infantile papular acrodermatitis (Gianotti-Crosti syndrome); 42/54 exanthema, 2/54 acute urticaria, 1/54 erythema multiforme, 1/54 erythema nodosum.Conclusion After reviewing the available literature on the subject and in the light of these findings, it is possible to assert that EBV-primary infection is not infrequently associated with skin symptoms. Clinicians may sometimes understimate the problem, and it would be useful to include EBV serology among the tests for the diagnosis of reactive cutaneous diseases occurring in subjects under 30 years old.

Ohjectives To investigate .skin disorders related to Epstein Barr Virus (EBV) seroconversion and review the literature on this topic.Patients and methods 77 patients admitted to three Departments (Dermatology, Infectious Diseases, Pediatrics) presented clinical and laboratory (Enzyme Linked Immunosorbent Assay) findings of EBV primary infection. 54/77 (70.1%), ranging in age from 9 months to 41 years and suffering from various skin disorders, were selected.Results 8/54 presented Infantile papular acrodermatitis (Gianotti-Crosti syndrome); 42/54 exanthema, 2/54 acute urticaria, 1/54 erythema multiforme, 1/54 erythema nodosum.Conclusion After reviewing the available literature on the subject and in the light of these findings, it is possible to assert that EBV-primary infection is not infrequently associated with skin symptoms. Clinicians may sometimes understimate the problem, and it would be useful to include EBV serology among the tests for the diagnosis of reactive cutaneous diseases occurring in subjects under 30 years old.

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