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Summary Serum IgA, IgG, IgM and C‐reactive protein levels were measured over a 12‐week period in 20 women using the intrauterine contraceptive device. No significant amount of serum C‐reactive protein was detected at any time. Alterations in the serum immunoglobulin levels are discussed.

uterine activi-ty were significantly greater in the oxytocin group than in the PGE2 group.In the augmentation series2 the difference between the two drugs was even nore apparent. The augmentation-to-delivery interval, the mean basal uterine tone, the mean frequency of contractions, nausea, vomiting, ketosis, pyrexia, and late fetal heart decelerations were all significantly higher in the oxytocin group than in the PGE2 group.Returning to Mr. Charnberlain's observation that preselection of high-risk infants may explain the findings of Mr. Liston and Mr. CaQbell, our data demonstrate that the oxytocic used is undoubtedly a contributory factor. They also show that this is less significant with PGE2 than with oxy,tocin. We therefore support Mr. Liston and Mr.Campbell's sugestion that the use of oxytocin can be hazardous and, while PGE2 appears to be kinder to the uterus and fetus, the possible dangers of all oxytocics should never be forgotten.-We are, etc.,