Introduction: The aim of this study was to evaluate the primary and secondary therapeutic successes of different therapy schemes for the treatment of synechia of the labia in pre-pubertal girls. Materials and Methods: The treatment courses of 47 pre-pubertal girls who were treated between February 2007 and February 2013 in the special outpatient clinic for paediatric gynaecology of a department for gynaecology at a German university hospital and for whom information on the course of the disease was available for at least the six months following end of the treatment. 23 of these children were treated with a topical estriol therapy (treatment group A). For 24 of the girls a manual separation of the adhering labia minora was undertaken (treatment group B). Statistical evaluation was performed using the ?2 test, Fischer?s exact test and the Mann-Whitney U test. Results: For 18 of the 23 (80?%) girls in treatment group A topical estriol therapy alone led to a resolution of the synechia. Five of these 23 children (20?%) required a secondary manual separation. All girls for whom treatment was not successful were under 5 years of age. For all 24 girls (100?%) of treatment group B the primary manual separation was performed with success. The recurrence rates after ??6 months in cases with identical after-care did not differ between the two treatment groups (treatment group A: 34?%, treatment group B: 33?%, ?2 test: p?=?0.853). 16 of the 17 recurrences occurred ??3 months after the end of the therapy. Conclusion: Our results show that for children

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Patients who underwent surgical procedures usually develop elevated body temperature, changes of plasma levels of some proteins, and leucocytosis. These alterations are summarized as the postoperative acute-phase reaction. Also endotoxin can induce the described phenomena suggesting that endotoxin may play a role concerning the induction of the acute phase reaction. In order to test that hypothesis we determined endotoxin plasma levels preoperatively and daily postoperatively in patients who were operated on because of goiter (n = 20), colonic, pancreatic and gastric diseases (n = 58). A significant increase of endotoxin plasma levels was found at the first and third day after abdominal surgery whereas after goiter surgery the increase revealed to be only very slight. However, the decrease between the first and second postoperative day in the latter group was again statistically significant suggesting postoperative endotoxemia even after minor operations. Furthermore a correlation between the amount of circulating endotoxin and pulmonary or infectious complications could be established in patients after major operations even at the first postoperative day suggesting a pathogenetic relevance of postoperative endotoxemia.