Pedigree analysis of ichthyosiz vulgaris in an extensive North German kindrcd revealed X-linked recessive inheritance. Only males were affected; heterozygous females had no sign of this dermatosis. Clinically and histologically, the disease resembled the autosomal dominant form. The differential diagnosis between this X-linked recessive ichthyosis vulgaris, ichthyosiz congenita mitis, and X-linked ichthyosis of the Wells-Kerr type is discussed. We conclude from our qtudy that ichthyosis vulgariz is genetically heterogeneous.

Pedigree analysis of ichthyosiz vulgaris in an extensive North German kindred revealed X‐linked recessive inheritance. Only males were affected; heterozygous females had no sign of this derma‐tosis. Clinically and histologically, the disease resembled the autosomal dominant form. The differential diagnosis between this X‐linked recessive ichthyosis vulgaris, ichthyosiz congenita mitis, and X‐linked ichthyosis of the Wells‐Kerr type is discussed. We conclude from our qtudy that ichthyosis vulgariz is genetically heterogeneous.