Background Few COVID-19 vaccines were anticipated in India in early 2021. However, little was known about COVID-19 vaccination acceptance among the public. . We conducted a nationwide study to understand the public’s perception about COVID-19 vaccines in December 2020. Method An online survey was deployed using a multi-item validated questionnaire via social media websites and networking platforms for adults in India. . We asked participants about vaccination willingness, concerns about vaccination, and their sociodemographic characteristics. Results Nationwide, 1638 participants from 27 states/union territories took the survey where the majority of the participant were males (55%), 18–30 years old (52%), urban dwellers (69%), college-educated (81%), without a history of COVID-19 infection (92%). More than a fifth were either unaware of the vaccines (20.63%) or were not sure if they will get the vaccine (27%), and 10% refused to obtain the vaccine. Almost 70% of the population had concerns regarding the vaccines. . Statistically significant differences (p<0.01) in awareness about vaccine and acceptability were observed based on age, educational qualifications, and employment status. Conclusion While the majority of Indians would accept the vaccine, given the large population of India, even a small proportion would translate to millions of unvaccinated individuals Strategic measures and policy decisions to enhance the rate of COVID-19 vaccination should be continuously planned and implemented in India.

The present study was aimed to formulate and evaluate floating tablets of indomethacin by wet granulation method. Indomethacin is used as a potent anti-inflammatory drug with prompt anti pyretic action, mainly used for the treatment of osteoarthritis with half-life of 4.5 hrs. Indomethacin is stable in neutral or slightly acidic media. In this study, excipients like HPMC 5cps, sodium bi carbonate were incorporated in a nine different concentrations (F1-F9) along with other excipients (PVP K30, lactose, talc, and magnesium stearate) to formulate floating tablets by wet granulation method. Then all the nine formulations were evaluated for uniformity of weight, hardness, thickness, friability test, floating lag time, drug content, dissolution studies and stability studies. The dissolution profile of trial-6 (formulation 6) was observed to be better than other formulations. In trial-6 indomethacin was formulated as a floating tablet by using HPMC 5cps (120 mg) as a matrix forming polymer and sodium bi carbonate (40 mg) as a gas generating agent. Trial-6 formulation showed a good dissolution profile for a controlled period of time which was noticed to be as 97.78 % at the end of 12 th hour. Thus, it can be concluded that the floating drug delivery system of indomethacin using the appropriate polymers in right amount may enhance the activity of the drug by prolonging the gastric residence time or reducing the floating lag time.