Lipomas are benign mesenchymal tumors. They are the most common type of soft tissue tumors. Intramuscular lipoma is a relatively uncommon condition and accounts for about1.8% of all primary tumors of adipose tissue and are relatively rare in upper extremity. When deep, large and unusual in location, magnetic resonance imaging (MRI) can identify and localise these tumours and is the best modality to differentiate lipoma and liposarcoma. We report an extremely rare and interesting case of giant intramuscular biceps brachii lipoma. A 22-year male patient presented with insidious onset, firm and non-tender swelling in the left elbow without any distal neurovascular deficits. MRI and biopsy were suggestive of lipoma. Wide local excision was done and patient had an uneventful recovery. Post-operative histopathology was suggestive of lipoma. To conclude, intramuscular giant lipoma of biceps brachii is an infrequent clinical entity due to its location. Imaging is necessary to differentiate it from its malignant counterpart and to plan surgical management.
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