Skin whitening, also known as skin lightening or skin bleaching, is utilizing chemical compounds to lighten or even out the skin’s colour by lowering the skin’s melanin concentration. The biosynthetic process of melanogenesis and the related main regulatory signaling pathways are summarized in this paper. It also addresses the efficacy of natural skin-whitening treatments based on their mode of action on melanogenesis and their compound classification. The review’s goal is to provide useful information and create awareness on the effects of bleaching cream.