Multisystem Inflammatory Syndrome (MIS-C) in children associated with SARS-CoV-2 infection has a variable clinical presentation because it affects many systems. It can affect the cardiac, renal, respiratory, hematological, gastrointestinal, dermatological, and neurological systems. If left untreated, it causes fatal complications. In this case report, a five-year-old male patient was admitted to the pediatric emergency service with complaints of fever, nausea, vomiting, abdominal pain, and loss of appetite. Physical examination revealed tenderness, defense, and rebound in the right lower quadrant of the abdomen. On ultrasound, the diameter of the appendix was determined as 6.8 mm. The patient, who was operated on for acute appendicitis (AA), was re-evaluated after fever and vomiting did not resolve, and he was diagnosed with MIS-C. This case was presented to remind that MIS-C should be excluded before the diagnosis of AA in patients with fever for more than 24 hours, gastrointestinal symptoms, and findings of AA.