Introduction: Psoriasis is a commonly occurring chronic skin disease which is characterized by recurrent erythematous skin plaques exhibiting epidermal hyperplasia accompanied by infiltration of varied inflammatory cells leading to abnormalities of the papillary dermal vasculature. Earlier studies postulated that the rise in serum uric acid levels which is observed in approximately 30 to 40 per cent of patients with psoriasis was due to the increased turn over in the skin.Objectives: Since there is scanty literature reports based on carbonic anhydrase activity is psoriatic skin disorder patients, the aim of our study to evaluate serum carbonic anhydrase activities, uric acid, and C -reactive protein levels and lipid parameters in various stage of psoriatic patients with the objectives to correlate the possible changes with the different clinical and biochemical parameters. Material & Methods:Forty-four psoriatic patients were enrolled for the present study for a period of one year and one month. The patients who attended skin OPD with psoriasis, confirmed with supportive clinical and histopathological findings, were included in the study. Serum uric acid levels and carbonic anhydrase activity were measured using standard procedure. All chemicals were procured from Sigma Chemicals, USA.Results And Conclusion: Serum Uric acid, Carbonic anhydrase activity and C-reactive proteins and lipid parameters were elevated in patients compared to controls. Of these the uric acid levels and carbonic anhydrase activities, serum triglyceride and LDL/HDL ratio were significantly elevated in patients. The study concludes all patients diagnosed of psoriasis must be equally predicted for future risk of cardiovascular diseases.

Background: Preeclampsia is a multisystem disorder that is characterized by hypertension and proteinuria in women with no history of hypertension and proteinuria. It is mainly caused due to an imbalance between the physiological vasoconstrictor and vasodilator molecules. Nitric oxide and hydrogen sulphide are well established vasodilatory endogenous gasotransmitters that exhibit reduced production from intrauterine tissues during preeclampsia. Aims and objectives: The aim of the study was to determine the serum levels of nitric oxide and hydrogen sulfide in preeclampsia cases compared with age matched controls and to rule out, whether there is a significant relationship if any, between these two gasotransmitters in preeclampsia. Materials and methods: Serum levels of NOx and H 2 S were measured in 100 pregnant women with preeclampsia and the values were matched with controls. Results: The mean serum NOx levels of preeclamptic patients was 45.88 ± 17.72 µmol/L which were significantly lower (p<0.001) than those observed in control with a values of 161.09 ± 27.46 µmol/L. The mean serum H 2 S level was 32.31 ± 12.62 µmol/L in patients which was significantly lower (p<0.001) when compared to control where mean we observed 114.50 ± 20.35 µmol/L. A positive correlation exists between serum NOx and H 2 S levels in preeclampsia (r=0.691, p<0.001). Conclusion: The present study has elucidated that the serum levels of nitric oxide and hydrogen sulfide decrease in preeclampsia compared to normal pregnant women and these two molecules show a positive correlation in their levels in preeclampsia.