This study aimed to inspect the presence of atropine and scopolamine alkaloids in two species of Datura (D. stramonium & D. innoxia) from different places in Iraq and Iran. The whole plant were collected, dried, mashed, and then extracted by using solvent system 15:15:1 (Chloroform/Methanol/Ammonia 25%) Determination of alkaloids was performed by high-performance liquid chromatography (HPLC) method using C18 column and isocratic mobile phase of acetonitrile-50 mM in phosphate buffer (pH 2.95). A comparative HPLC investigation of the alkaloid showed that there are significant differences in the quantities of the alkaloids in the plants of different origin, indicating that the influence may be attributed to the environmental factors.
With the spreading of Covid-19 and seeking for a drug that helps people around the world to cure this disease.In this article, we used a plant(Cassia fistula) which is rich in anthraquinone glycosides to control the causative agent. Anthraquinone was extracted from Cassia fistula pods using alcohol method.Antioxidant activity of the extracted anthraquinone was analysed by using hydrogen peroxide scavenging assay.The best inhibition assay was 70% at100mg/mlconcentration. The docking study introduced atheoretical explanation for an interaction between two types of anthraquinone glycosides (rhein and aloe-emodin) in Cassia fistula against the main protease (7BZ5) in SARS-COV-2 virus, which gave a good binding energy score as -5.36491489 and -5.48040009 for rhein and aloe-emodin, respectively.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.