Objective:To measure the concentration of fetuin-A in serum and follicular fluid of patients with PCOS at day of ova pick up after using of different IVF/ICSI protocols and to assess the pregnancy outcome. Study design: A total of 90 infertile women (55 women with Polycystic ovary syndrome and the other 35 women as a control (non PCOS) undergoing controlled ovarian hyperstimulation for intracytoplasmic sperm injection cycle were prospectively recruited for this study in High Institute of Infertility Diagnosis and Assisted Reproductive Technology / AL-Nahrian University and Kamal ALSamarai Hospital, center of fertility and IVF (Baghdad/Iraq) during the period from December 2015 to the end of April 2017.The fifty five PCOS women were divided into three groups: twenty five (25) infertile women have had PCOS undergoing long Agonist protocol for ICSI cycle, fifteen (15) infertile women have had PCOS undergoing Antagonist protocol for ICSI and fifteen (15) infertile women have had PCOS undergoing short Agonist protocol for ICSI. The controlled group included 35 women were free of signs and symptoms of PCOS with regular cycles and no endocrine abnormalities undergoing ICSI cycle (15 infertile women underwent long agonist protocol, 10 women underwent short agonist and 10 women underwent antagonist protocol). In all patients, serum and follicular fluid fetuin-A levels were measured on the day of oocyte retrieval by using Enzyme linked immuno sorbent assay. Results: There was significant difference (p<0.05) in the level of fetuin-A in follicular fluid between PCOS and control group. Follicular fluid fetuin-A level was high in non PCOS patients than PCOS patients but no significant difference (p>0.05) in the level of fetuin-A in serum between PCOS and control group. Also there was no significant difference in the effect of different IVF/ICSI protocols (Long agonist, Antagonist, Short agonist) in the level of follicular & serum fetuin-A of patients with PCOS (P>0.05) and no significant difference (P>0.05) in level of serum and follicular fluid fetuin-A between pregnant &non pregnant PCOS patients. ž Conclusion: It was concluded from the present study that FF fetuin-A concentration of PCOS patients at the day of oocyte retrieval is significantly lower than that of non PCOS patient. But no significant