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Transcranial ultrasound has been used to image the brain since 1942. Currently, it is regaining interest and full-waveform inversion (FWI) methods are now employed to reconstruct speed-of-sound profiles of the brain. Many of these methods require a good starting model. Here, we test the applicability of contrast source inversion (CSI) as a FWI method to reconstruct two-dimensional speed-of-sound profiles of the soft brain tissue enclosed by the skull. The advantage of CSI is that it can handle large acoustic contrasts without the need for a good starting model. To test the performance of CSI, we first compute synthetic data. The resulting pressure field clearly shows a significant amount of multiple scattering caused by the skull that acts as a hard acoustic contrast. Next we invert the resulting synthetic data within the Born approximation as well as by applying CSI as a FWI method. The results clearly show that Born inversion can only image the soft brain tissue in the absence of the skull whereas it generates erroneous results when the skull is present. On the other hand, with CSI it is feasible to reconstruct both the skull and the soft brain tissue accurately. Importantly, as compared to other methods CSI does not require any a priori information about the contrast, a mask or a heterogeneous starting model to reconstruct the soft tissue enclosed by the skull.

Whole breast ultrasound scanning systems are used to screen a women's breast for suspicious lesions. Typically, the transducers are located at fixed positions at relatively large distances from the breast to avoid any contact with the breast. Unfortunately, these large distances give rise to large spatial domains to be imaged. These large domains hamper the applicability of imaging by inversion. To reduce the size of the spatial computational domain, we present a two-dimensional redatuming method based on Hankel decomposition of the measured field. With this method, the field measured over an arbitrary-shaped closed curve can be redatumed to a new curve enclosing a smaller spatial domain. Additional advantages of the proposed method are that it allows to account for the finite size and orientation of a transducer and that it is robust to noise. The proposed method is successfully validated using synthetic and measured data and the results show that the recorded field can be redatumed to any position in the embedding. Index Terms-redatuming, full-wave inversion, 2-D breast ultrasound.

Multi-parameter inversion for medical ultrasound leads to an improved tissue classification. In general, simultaneous reconstruction of volume density of mass and compressibility would require knowledge of the particle velocity field alongside with the pressure field. However, in practice the particle velocity field is not measured.Here, we propose a method for multi-parameter inversion where the particle velocity field is reconstructed from the measured pressure field. To this end, the measured pressure field is described using outward propagating Hankel functions. For a synthetic setup, it is shown that the reconstructed particle velocity field matches the forward modelled particle velocity field. Next, the reconstructed particle velocity field is used together with the synthetically measured pressure field to reconstruct density and compressibility profiles with the aid of contrast source inversion (CSI).Finally, comparing the reconstructed speed of sound profiles obtained via singleparameter versus multi-parameter inversion shows that multi-parameter outperforms single-parameter inversion with respect to accuracy and stability.