The authors describe what is, to the best of their knowledge, the first quantitative hemoglobin concentration images of the female breast that were formed with model-based reconstruction of near-infrared intensity-modulated tomographic data. The results in 11 patients, including two with breast tumors with pathologic correlation, are summarized. Hemoglobin concentration appears to correlate with tumor vascularity without the need for exogenous contrast material and thereby has intrinsic diagnostic value.

Diffuse tomography with near-infrared light has biomedical application for imaging hemoglobin, water, lipids, cytochromes, or exogenous contrast agents and is being investigated for breast cancer diagnosis. A Newton-Raphson inversion algorithm is used for image reconstruction of tissue optical absorption and transport scattering coefficients from frequency-domain measurements of modulated phase shift and light intensity. A variant of Tikhonov regularization is examined in which radial variation is allowed in the value of the regularization parameter. This method minimizes high-frequency noise in the reconstructed image near the source-detector locations and can produce constant image resolution and contrast across the image field.

Efficient frequency doubling of a cw Q-switched and mode-locked Nd:YAG laser has been observed in commercial single-mode optical glass fibers. Pulses of duration ~55 psec and intensities as high as ~0.55 kW were produced at 0.53 microm. The maximum peak power-conversion efficiency measured was ~3%. The frequency-doubled light generated in the glass fibers was sufficient to pump a commercial Rh6G dye laser with ~19% efficiency at 570 nm.

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