The article presents the results of research on the state and development of export-oriented small and medium-sized enterprises and the reasons of the incomplete implementation of the export capacity of enterprises. Among the priority constraints on the development of export-oriented small and medium-sized enterprises have been allocated financial and administrative constraints. The most effective mechanisms to support SMEs are subsidizing the cost of promoting products to the world market and the compensation of interest rates on export contracts. Found that most of the export-oriented SMEs are interested in increasing the share of exports and seek to expand the geography of deliveries, but for the realization of their interests is necessary to improve infrastructure support. Each regional education puts its emphasis in the export development strategy for small and medium enterprises. Based on a comparative analysis of the existing Coordination centers of export-oriented SMEs of Russian Federation subjects support, determined the possibility of approximating the existing mechanisms for support of small and medium-sized export-oriented entrepreneurship Voronezh region. The process of ensuring the establishment of effective mechanisms to support export-oriented small and medium-sized enterprises Voronezh region includes two time periods transient (lasting less than a year) and operational for over a year.