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The EU Framework 7 project SPIDIA was the occasion for development of NMR approaches to evaluate the impact of different pre-analytical treatments on the quality of biological samples dedicated to metabolomics. Systematic simulation of different pre-analytical procedures was performed on urine and blood serum and plasma. Here we review the key aspects of these studies that have led to the development of CEN technical specifications, to be translated into ISO/IS in the course of the EU Horizon 2020 project SPIDIA4P. Inspired by the SPIDIA results, follow-up research was performed, extending the analysis to different sample types and to the different effects of long-term storage. The latter activity was in conjunction with the local European da Vinci Biobank. These results (which partially contributed to the ANNEX of CEN/TS 16945"MOLECULAR IN VITRO DIAGNOSTIC EXAMINATIONS -SPECIFICATIONS FOR PRE-EXAMINATION PROCESSES FOR METABOLOMICS IN URINE, VENOUS BLOOD SERUM AND PLASMA") are presented in detail.

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With the publishing of Metaphors we live by in 1980, Lakoff & Johnson introduce the Cognitive Metaphor Theory, which rules out the traditional view of metaphor as restricted to its exclusively linguistic use, perceived as an unusual and isolated figure of rhetoric discourse. In contrast, metaphor now is seen as an expression of deeper conceptual structures underlying cognitive capacities in general which help us construct our reality and world view. However, conceptions emphasizing these prescriptive and exploring functions of metaphor already can be found in an explicit way in the metaphorology of Hans Blumenberg as well as in the theory about image fields formulated by the linguist Harald Weinrich. The article deals with the question to what extend these two conceptions already anticipate the Cognitive Metaphor Theory. KeywordsCognitive Metaphor Theory; Metaphorology; Image field giving/ receiving.

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