In modern world persons addicting to drugs are increasing gradually. Smoking, cocaine, nicotine etc. are harmful to human body. The most commonly affected organs are lung, liver, kidney. But the effect of nicotine is more in lungs which affect blood concentration and heart rate, analyzed using Physiologically Based Toxico-Kinetics and Physiologically Based Toxico-Dynamics modeling. The person affected by heart disease also has chance for lung failure. Best and safe method for avoiding lung failure is lung transplantation and fixing Artificial Lung (AL). In lung transplantation both the donor and recipient requirement should perfectly match, in Artificial Lung method any one of the lung assisting device is fixed instead of original lungs, but it is not analyzed effectively. In order to improve its efficiency the compliance chamber is designed and kept in between heart and lungs. By which the pulmonary artery pressure is maintained in the range between 8 to 25 mm/Hg.