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Twelve new analogues of gabapentin (GBP) derived hydrazide-hydrazone scaffolds were produced by using various electronically and structurally divergent aromatic aldehydes. All the hydrazones were obtained in moderate to good yields (66-82%) by heating the GBP hydrazide with respective aldehydes to a temperature of 45-65 °C for 4-7 h. Further, the compounds were explored for their antimicrobial activity on three different Gram positive (Micrococcus luteus, Streptococcus mutans, Enterococcus faecalis) and Gram negative bacterial strains (Salmonella enterica, Alcaligenes faecalis, Pseudomonas aeruginosa). The antibacterial results obtained were found to be good against Gram positive bacteria when compared to Gram negative bacteria. Moreover, the compounds were also screened for antioxidant activity at four different concentrations using the DPPH method and the results showed that some of the compounds were moderately active.

A NEW series of Bezafibrate derived hydrazide-hydrazone analogues were generated by using some five membered, fused heterocyclic and aromatic aldehydes. All the hydrazones were obtained in good yields from methanol at 60-80 °C for 5-8 hours stirring. Moreover, the compounds were also screened for their anti-oxidant activity potentiality at four different concentrations using DPPH method. Among these compounds, compound 6k analogue of bezafibrate was found to be the most active at all the tested concentrations (≈ 40% inhibition at 25 μg/mL) followed by 6j (4-hydroxy, 3-methoxy 5-bromo analogue ≈ 35% at 25 μg/mL) compared to standard ascorbic acid (49.6% at 25 μg/mL).

Some new analogues of trifluoromethylphenyl acrylic acid scaffold derived hydrazide-hydrazones (4a-l) were produced by using various structurally divergent aromatic aldehydes. All the hydrazones were obtained in moderate to good yields (64-78%) in methanol at a temperature of 45-65 °C. All the compounds were screened for antioxidant activity by DPPH method and the compounds 4c, 4d, 4e and 4h were found to be showed maximum antioxidant activity among the synthesized compounds.

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