The aim of this study was to compare efficacy and safety of Allium Curcuma with glibenclamide in type-2 diabetes mellitus with or without dyslipidemia. Thirty five patients were recruited and randomized into 2 groups for 14 weeks treatment and assessment. One group received study drug, three times two capsules containing 200 mg turmeric and 200 mg allium extract per day. The other group received 1 capsule of 5 mg glibenclamide as standard drug per day. After 14 weeks of treatment patients with allium curcuma treatment showed significant decreased in fasting blood glucose (192.76 versus 141.71 mg/dL) and 2 hours post-prandial blood glucose (295.35 versus 204.35 mg/dL). HbA1C level was also significantly decreased (10.41 versus8.09). No difference was found in blood pressure, hematology profile, liver and kidney function of both groups. In conclusion, allium curcuma has potential to be used as antidiabetic agent.

Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonas aeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 mm of inhibition zone on 1 mg/ml concentration, respectively. There was no increased effect from the combination of these two extracts against these bacteria. When comparing the antibacterial activity of these extract with tetracycline as the standard, we found that antibacterial activity of P. indica at the concentration of 0.9 mg/ ml was comparable with that of tetracycline at concentration of 12.52 μg/ml, while P. betle needed 0.3 mg/ml concentration to had similar activity with 10.51 μg/ml of tetracycline. In conlusion, the antibacterial activity of ethanol extracts of P. indica and P. betle indicated that these extract had sufficient potential to warrant further examination and development as a new antibacterial agent.

Abstract. Suji leaf (Draceana angustifolia) is one of the natural materials that has been widely used by people, one of them is used as a medicinal plant. Its manufacture as a medicinal plant can’t be separated from manufacture into the form of Simplicia. Each simplicia must be guaranteed in terms of quality, efficacy, and safety. Based on this, the problem in this research is formulated as follows: (1) What are the characteristics of suji leaf simplicia based on specific and non-specific parameters? (2) What are the groups of secondary compounds/metabolites contained in simplicia and ethanol extract of suji leaves? Determination of specific parameters including the determination of the water-soluble extract content and the determination of the ethanol-soluble extract content. Then for non-specific parameters including the determination of water content, determination of drying shrinkage, determination of total ash content, and determination of acid insoluble ash content. For phytochemical screening, the test is carried out by the color test method using specific reagents. The results of this research were: For the determination of the water-soluble extract content and the determination of the ethanol-soluble extract content were 12.67% and 5.84%, respectively. The results for the determination of the water content of 7.99%, the determination of drying shrinkage of 9.69%, the determination of the total ash content of 6.39%, and the determination of the acid insoluble ash content of 0.45%. The simplicia and ethanol extract of suji leaves contain several classes of chemical compounds/secondary metabolites including phenolic compounds and terpenoids. Abstrak. Daun suji (Draceana angustifolia) merupakan salah satu bahan alam yang telah banyak dimanfaatkan oleh masyarakat. Pemanfaatan daun suji juga sudah berkembang untuk digunakan sebagai tanaman obat. Dalam  pembuatannya sebagai tanaman obat tidak lepas dari pembuatannya ke dalam bentuk simplisia. Setiap simplisia haruslah terjamin dalam hal mutu, khasiat dan keamanannya. Berdasarkan hal tersebut, maka rumusan masalah pada penelitian kali ini yaitu: (1) Bagaimanakah karakteristik simplisia daun suji berdasarkan parameter spesifik dan parameter non spesifik? (2) Apa sajakah golongan senyawa/metabolit sekunder yang terkandung pada simplisia maupun ekstrak etanol daun suji?. Penetapan parameter spesifik yang dilakukan meliputi penetapan kadar sari larut air dan penetapan kadar sari larut etanol. Kemudian untuk parameter non spesifik yang dilakukan yaitu penetapan kadar air, penetapan susut pengeringan, penetapan kadar abu total dan penetapan kadar abu tidak larut asam. Untuk penapisan fitokimia pada simplisia maupun ekstrak etanol daun suji dilakukan dengan metode uji warna dengan menggunakan pereaksi spesifik. Hasil dari penelitian ini adalah: Hasil penetapan kadar sari larut air dan penetapan kadar sari larut etanol berturut-turut adalah 12,67% dan 5,84%. Hasil untuk penetapan kadar air 7,99%, penetapan susut pengeringan 9,69%, penetapan kadar abu total 6,39% dan penetapan kadar abu tidak larut asam 0,45%. Pada simplisia dan ekstrak etanol daun suji mengandung beberapa golongan senyawa kimia/metabolit sekunder diantaranya adalah senyawa fenolik dan terpenoid.

Syzygium is a genus of the Myrtaceae family consisting of large and widespread species from Africa, Asia, Australia, and throughout Oceania and the Pacific region. Some have been cultivated for bearing fruit, ornamental plants and used as traditional medicine. This article excavated Syzygium genus which was focused on traditional uses, chemical compounds and biological activities related to treatment of syndrome metabolic. All information was obtained from the scientific literature such as Science Direct, Google Scholar, Scopus and PubMed. Several species were known to have therapeutic potential and used in traditional Chinese medicine, Ayurveda, and herbal medicine in Indonesia. Traditionally, Syzygium is known for its therapeutic purposes such as coughing, diarrhea, colds, dysentery, inflammation, pain, skin, and mouth infections. Only a few species have been scientifically studied to verify their usage as traditional medicine. There were many reports on the traditional uses and medicinal effects of Syzygium plants, but only a few review articles mainly about phytochemical constituents and their role in pharmacological activities. The present reviews highlight the phytochemical and pharmacological activity of various species of the Syzygium genus. The pharmacological activities were discussed in this article focused to metabolic syndrome treatment, such as antidiabetic, antihyperlipidemic, antioxidant and antihypertensive activities. Chemical components isolated mainly flavonoid, terpenoids/sesquiterpenoid, sterols, and lignan. Several bioactive compounds have been identified correlated with pharmacological activity, but the chemical compounds were different for each species.

Abstract. Public knowledge of disease is important for achieving a better quality of life so that they will care and comply with drug identification, so that errors do not occur, in dealing with health problems or medication errors. Understanding of performing an act of self-medication of disease is very necessary because the slightest mistake made by the patient will be fatal and even death. Based on the survey results, in general, people are more likely to do self-medication if they feel a health symptom. Such as, influenza, fever, diarrhea, ulcers (gastritis) and others, with only minimal educational knowledge and information. light. The perceived benefits of self-medication include drugs that are easy to obtain because they are sold freely in stalls, pharmacies and drug stores. Without having to attach a doctor's prescription. Thus, the cost of treatment is cheaper. According to information, disease data from the Cikole Community Health Center in Lembang District shows that the disease occupies the top 6 every month (Cikole Public Health Center, 2021). The purpose of this study was to determine the extent of understanding of the community in Cikole Village, Lembang District in identifying the right drug, using descriptive research methods through questionnaires. which are often used are Antacids (91.1%), tablet dosage forms (66.6%) and in the use of gastritis drugs and their storage are in the good category (86.43%). Abstrak. Pengetahuan masyarakat terhadap penyakit merupakan hal penting untuk tercapainya kualitas kehidupan yang lebih baik sehingga akan peduli dan patuh terhadap identifikasi obat, agar tidak terjadi kesalahan dalam menangani masalah kesehatan atau medication error. Pemahaman melakukan suatu tindakan swamedikasi penyakit sangatlah diperlukan karena kesalahan sedikit saja yang dilakukan penderita akan berakibat fatal bahkan kematian. Berdasarkan hasil survei pada umumnya masyarakat lebih cenderung melakukan swamedikasi apabila merasakan suatu gejala kesehatan. Seperti, influenza, demam, diare, maag (gastritis) dan lainnya, dengan hanya berbekal pengetahuan edukasi dan informasi yang minim. swamedikasi merupakan penggunaan obat oleh seseorang untuk pengobatan diri sendiri berdasarkan diagnosa gejala sendiri, tanpa berkonsultasi dengan dokter biasanya dilakukan dalam mengatasi keluhan penyakit ringan. keuntungan yang dirasakan dari swamedikasi obat mudah didapat karena dijual bebas diwarung, Apotek dan toko obat. tanpa harus dilampirkan resep dokter. Sehingga, biaya berobatpun lebih murah. Menurut informasi data penyakit dari Puskesmas Cikole Kecamatan lembang bahwa penyakit gastritis setiap bulannya menempati 6 besar (Puskesmas Cikole, 2021). Tujuan penelitian ini untuk mengetahui sejauh mana pemahaman masyarakat Desa Cikole Kecamatan lembang dalam mengidentifikasi obat yang tepat, dengan menggunakan metode penelitian deskriptif. dan penyebaran melalui kuesioner, dari hasil penelitian disimpulkan bahwa pengetahuan masyarakat Desa Cikole pada swamedikasi penyakit gastritis termasuk kategori baik (90,79%) obat yang sering digunakan adalah golongan Antasida (91,1%), bentuk sediaan tablet (66,6%) dan dalam penggunaan obat gastritis dan penyimpanannya termasuk kategori baik (86,43%).