No abstract

Background: Various abnormalities of coagulation have been reported in patients with overt hypothyroidism. The coagulation abnormalities may result in mild bleeding tendency to profuse bleeding after any trauma or surgery in overt hypothyroid patients. Objective: To assess the coagulability status in overt hypothyroid patients by estimation of plasma factor VIII level and total count of platelets. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from January 2016 to December 2016. Twenty overt hypothyroid patients with age ranging from 18 to 55 years were selected as study group and twenty healthy subjects were considered as control group. Patients were selected from Outpatients Department of Endocrinology and Nuclear Medicine & Allied Sciences of Dhaka Medical College Hospital, Dhaka. For assessment of coagulability state, plasma factor VIII level and total counts of platelet were estimated by automated analyzer. For statistical analysis unpaired Student ‘t’ test, Chi square test were used. Results: Total count of platelet and plasma factor VIII level were significantly lower (P<0.001) in overt hypothyroid patients. Conclusion: This study concluded that overt hypothyroid was associated with hypocoagulability and therefore these patients are at higher risk of bleeding tendency. J Bngladesh Soc Physiol 2021;16(1): 77-81

Surgical menopause can be defined as cessation of menstruation due to surgical removal of the uterus (hysterectomy), leaving one or both ovaries, or the removal of both ovaries. Women who undergo hysterectomy alone are known to attain menopause 3.7 years earlier than those who attain natural menopause due to decrease blood supply to ovaries. These women face severe postmenopausal symptoms due to deficiency of serum estradiol. Deficiency of serum estradiol is also associated increase bone resorption and decrease renal excretion of phosphate resulting hyperphosphatemia. Thus, increase risk of osteopenia and osteoporosis may present in surgical menopausal women. Very few studies are conducted to know the effect of endocrinological changes associated with hysterectomy on the serum level of phosphate. Hence the present study was conducted to compare the serum phosphate level in surgical (hysterectomies) and natural menopausal women. This cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, and Dhaka from July 2016 to June 2017. A total number of 60 women were selected with age ranging from 30 to 55 years. Among them, 40 menopausal women were considered as the study group B and 20 apparently healthy pre-menopausal women were considered as control group A. Study group B was again subdivided into group B1 and B2. Group B1 consisted of 20 natural menopausal women and group B2 consisted of 20 surgical menopausal (hysterectomies) women. Serum phosphate level was measured by Beckman Coulter AU680. Statistical analysis was done by one-way ANOVA followed by Bonferroni test. In this study, serum phosphate level was significantly (p < 0.05) increase in surgical menopausal women than natural menopausal women. Again, this study showed that 55.0% surgical menopausal and 40.0% natural menopausal women had serum phosphate level >4.7 mg/dl. From this study, it can be concluded that after hysterectomy serum phosphate level significantly increase which might be due to hormonal imbalance.