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The interaction of two copper(II) complexes, namely [Cu(L 1 )Cl 2 ] 2 (1) and [Cu(L 2 )Cl 2 ] 2 (2), where L 1 = 1-amidino-O-methylurea and L 2 = N-(benzyl)-amidino-O-methylurea, with DNA has been thoroughly investigated using different characterization techniques, including electronic absorption spectroscopy, viscosity measurements, fluorescence spectroscopy, circular dichroism spectroscopy, thermal denaturation, stoichiometric determination, gel electrophoresis and atomic-force microscopy. The coordination compounds exhibit DNA binding potential by non-intercalation and DNA-cleaving ability through the oxidative pathway. Indeed, both complexes display antibacterial properties (against three bacteria involved in human-food poisoning, i.e.Salmonella, E. coli and Campylobacter). Furthermore, their cytotoxicity has been tested against three cancer cell lines, which are the small cell lung carcinoma (NCI-H187), the oral cavity carcinoma (KB) and the breast adenocarcinoma (MCF-7) and it was revealed that they are more cytotoxic than cisplatin against the NCI-H187 cancer cell line.

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Four novel copper(ii) complexes based on guanidine derivatives have been synthesized by addition of N,N-heterocyclic ligands, and their interesting biological activities have been evaluated.

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