Original Research Article Background: The study aimed to evaluate the relationship between Diabetic neuropathy and neutrophil lymphocyte ratio amongst patients with type 2 diabetes. Methodology: The study was conducted as a cross sectional study in outpatient Department of Medicine, Hamidia Hospital Bhopal for a period of 6 months. All the 100 known cases of type 2 diabetes belonging to age group of 18 to 80 years and giving consent were included in the study. Detailed data regarding sociodemographic variables, diabetes duration and treatment was obtained and entered in questionnaire. Height, weight, BMI was recorded. CBC, FBS, PPBS and HbA1c was also conducted. Results: The present study observed no statistically significant association between various baseline variables and Neutrophil to lymphocyte ratio (p>0.05).Neutrophil to lymphocyte ratio were significantly associated with duration of diabetes and presence of neuropathy i.e. NLR were significantly higher in patients with neuropathy and patients with longer duration of diabetes (p<0.05). Diabetic neuropathy was observed to be significantly correlated with neutrophil to lymphocyte ratio and duration of diabetes (p<0.01). Conclusion: Higher neutrophil to lymphocyte ratio may be considered as a prognostic indicator of diabetic neuropathy. This is a cost effective marker that is easily available and can be used in community settings as well as resource poor settings.