To date, linezolid-resistant S. epidermidis have rarely been isolated from human clinical sources in Germany. Here, we describe the emergence and outbreaks of these strains. We detected previously described and novel point mutations in the 23S ribosomal genes. The cfr gene was only present in six isolates. However, this is the first known description of cfr incorporation into conjugative vectors; under selective pressure, these vectors could give reasonable cause for concern.

We report the case of a 19-yr-old boy, who received an allogeneic stem cell transplantation for the second relapse of Hodgkin's disease. The patient developed seizures and flaccid hemiparesis on day +10. Meningoencephalitis induced by Bacillus cereus was diagnosed. The treatment consisted of appropriate antibiotics, G-CSF and removal of the central venous line. Infection control and nearly full neurological recovery was achieved. Immunocompromised patients susceptible to B. cereus infection, indicated by the isolation of B. cereus in prior cultures, should receive antibiotic treatment covering B. cereus.