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In this work, reduced graphene oxide-nickel (RGO–Ni) nanocomposite is synthesized. X-ray diffraction (XRD), scanning electron microscopy (SEM) and SEM–EDS (Energy Dispersive X-Ray Spectroscopy) are used to study the crystalline nature, morphology and elemental composition of the RGO–Ni nanocomposite, respectively. As synthesized RGO–Ni nanocomposite is used to develop selective adsorptive removal of Rhodamine B (RhB) dye from the aqueous solution. The experiments have been performed to investigate RhB uptake via RGO–Ni nanocomposites which include, contact time (60 min), initial dye concentration (50 mg/100 ml), adsorbent dosage (0.5 mg) and pH 8 of dye solution. The equilibrium concentration is determined by using different models namely, Freundlich, Langmuir and Tempkin. Langmuir isotherm has been fitted well. Langmuir and Tempkin equations are determined to have good agreement with the correlation coefficient data. The kinetic study concluded that RhB dye adsorption follows with the pseudo-second-order kinetic model. Further, adsorption mechanism of RGO–Ni is proposed which involves three steps. The synthesized adsorbent is compared with the other adsorbents in the literature and indicates that RGO–Ni nanocomposite used in this study shown better results for a particular adsorption capacity than polymeric, natural and synthetic bioadsorbents. The regeneration and reusability experiments suggest RGO–Ni nanocomposite can be used for many numbers of times for purification/adsorption.

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In present study, a series of 3-[(5-methyl-1,3-benzoxazol-2-yl)amino]-2-phenyl-2,3-dihydro-4H-1,3- benzothiazin-4-ones (6a-n) were synthesized and elucidated by elemental, FT-IR, 1H & 13C NMR and LC-MS studies. The in vitro antibacterial screening against Gram-positive bacterial strains such as B. subtilis, S. aureus, S. epidermidis and Gram-negative bacteria such as E. coli, P. aeruginosa was carried in comparison with tetracycline as reference standard. Antifungal activities against different fungal strains namely R. oryzae, A. niger, A. favus, C. albicans and S. cerevisiae have been evaluated by comparing with fluconazole as reference standard. Compounds 6b, 6c, 6e, 6j, 6m and 6n emerged as highly potent antimicrobial agents. The DPPH radical scavenging assay of the synthesized moieties showed good antioxidant potency comparable to standard ascorbic acid. The molecular docking simulation studies of all the title compounds in their active conformation analogues with target proteins (PDB ID 2XCT-antibacterial, PDB ID 1IYL-antifungal, PDB ID 2HCK- antioxidant) exhibited good binding interactions in top scoring poses. The pharmacokinetic properties prediction by ADMET descriptors and Lipinski′s rule of five endorse the properties of newly synthesized compounds to a drug molecule. The results of the docking protocols were compatible with the in vitro studies which validates the potency of the molecules.