No abstract

Synthesis of various highly functionalized caged systems suitable for high energy density materials was accomplished by utilization olefin cross metathesis strategy. Here we observed 100% E selectivity during cross-metathesis by using Grubbs II and N-tolyl Grubbs catalyst. The stereochemistry of olefin formed by cross-metathesis has been determined unambiguously by single-crystal X-ray diffraction study.

Herein, we report synthesis of various highly functionalized caged systems suitable as high energy density materials which were assembled by utilization of an olefin cross-metathesis strategy. We observed E-selectivity during the cross-metathesis by using Grubbs second generation catalyst (G-II) and N-tolyl Grubbs catalyst in most of the cross-metathesis products. The stereochemistry of the olefin formed during the cross-metathesis has been determined unambiguously by a single-crystal X-ray diffraction study.

We report various unusual amino acid derivatives containing heterocycles and heteroatoms (S, O, N) via diethyl acetadimalonate as a glycine equivalent and carried out further chemical transformations to modify these unusual amino acid derivatives. Sulfur‐containing halo and alkene derivatives are prepared, and these substrates are further modified by Suzuki‐Miyaura cross‐coupling reaction, cross metathesis sequence and selective formation of sulfoxide and sulfone derivatives. We also report oxazole‐containing amino acid derivative by using TosMIC.

Here, we have developed a simple synthetic approach towards synthesis of [5/6/5] and [5/5/5] fused carbocyclic frameworks from bis‐adducts of norbornadiene and cyclohexadiene derivatives with 1,2,3,4‐tetrachloro‐5,5‐dimethoxycyclopentadiene by employing atom‐economic ring‐rearrangement metathesis as a key step and these ring systems are core units in natural products. Here, we have designed highly congested polycyclic frameworks and introduced molecular complexity in a minimum number of steps. These targets contain up to seven stereo centres. Hence, this strategy can be used to design many different drug‐like molecules valuable in medicinal chemistry.