A BSTRACT Objectives: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of unknown etiology, mainly affecting female of child-bearing age group. Clinical scenario of SLE is not well defined in east region of India, especially in tribal region of Jharkhand. This article is mainly focused on clinical and laboratory characteristics of SLE in tribal region of Jharkhand. Materials and Methods: This was an analytical cross-sectional single-centered study conducted at RIMS, Ranchi, a tertiary care center of Jharkhand, between November 2020 and October 2021. A total 50 patients were diagnosed as SLE based on Systemic Lupus International Collaborating Clinics criteria. Results: Forty-five (90%) of patients in our study were female, with female to male ratio of 9:1. The mean age of presentation was 26.78 ± 8.12. Constitutional symptoms were found in 96% of patients, followed by anemia in 90% of patients. Renal involvement was found in 74% of patients, followed by polyarthritis (72%), malar rash (60%), and neurological manifestations (40%). Anti-nuclear antibody, anti-dsDNA, and anti-Smith antibodies were found positive in 100%, 84%, and 80% of patients, respectively. Conclusions: Clinical characteristics of SLE as per our study would help the health care professionals in this region to identify the disease at early stage and initiate appropriate treatment.

Introduction Stroke is a devastating and disabling cerebrovascular disease with a significant amount of residual deficit. The prevalence of stroke is in a rising trend in India. Larger studies are needed for the evaluation of risk factors. Material and methods This cross-sectional study aimed to assess the clinical profile of patients with stroke. The demographic details of the patients were taken, comorbidities were noted, and laboratory tests were done. Observation The most common age group who presented with stroke was 61-80 years, followed by 41-60 years, comprising 47% and 46%, respectively. Ischemic stroke was more common (60%) than hemorrhagic stroke (40%). Male patients were more than female patients. Alcohol, smoking, hypertension, diabetes, anemia, and proteinuria were present in the study group. Conclusion Regular evaluation of blood pressure, blood sugar, lipid profile, and proteinuria should be routinely done in patients with diabetes and hypertension who are more than 40 years old.

Introduction: Corona virus disease- 2019 is caused by severe acute respiratory syndrome- 2 (SARS-CoV-2), also known as Novel corona virus (2019-nCoV).The disease presentation ranges from asymptomatic to severe acute respiratory failure requiring intensive care support. There are multiple drugs, therapies, and vaccine trials underway. One such therapy is convalescent plasma. Passive immunity delivered as anti-corona virus antibodies from convalescent human plasma has promise of emerging as a therapeutic option in the treatment of SARS-CoV-2. Objective: The objective of the study is to determine blood group distribution among covid -19 convalescent plasma donors in the Department of blood bank, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand. Materials and Methods:Aretrospective study was conducted at Department of blood st st bank, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand over a period of 3 months from 01 August to 31 October 2020 who have donated at least one unit of convalescent plasma. Results: This study recorded greater number of male donors with B Positive blood group. The convalescent plasma donors were mostly middle aged between 30 to 50 years of age.

Introduction: Corona virus disease- 2019 is caused by severe acute respiratory syndrome- 2 (SARS-CoV-2), also known as Novel corona virus (2019-nCoV).The disease presentation ranges from asymptomatic to severe acute respiratory failure requiring intensive care support. There are multiple drugs, therapies, and vaccine trials underway. One such therapy is convalescent plasma. Passive immunity delivered as anti-corona virus antibodies from convalescent human plasma has promise of emerging as a therapeutic option in the treatment of SARS-CoV-2. Objective: The objective of the study is to determine the age and sex distribution of the recipients of the convalescent Covid 19 plasma among patients admitted at different hospitals in Ranchi, Jharkhand. Materials and Methods: A retrospective study was conducted at Department of blood bank, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand from July 28, 2020 to October 28, 2020 who received at least one convalescent plasma transfusion for hospitalized patients aged 18 years or older with moderately as well as severely ill or life-threatening COVID-19 disease within 21 days from the onset of their illness. Results: This study recorded greater number of male recipients with B Positive blood group. The convalescent plasma recipients were mostly old patients above 50 years of age.

Introduction: Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as novel coronavirus (2019-nCoV). The disease presentation ranges from asymptomatic to severe acute respiratory failure requiring intensive care support. Anti-SARS-CoV-2 IgG antibodies are developed either by natural infection from SARS-CoV-2 or by vaccination against COVID-19. The persistence of IgG antibodies allows identification of the people who have been infected in the past, recovered from illness, and possibly become immune. 7 IgG detection and other serological assays will play an important role in research and surveillance. Aims and Objective: The objective of the study is to assess anti-SARS-CoV-2 IgG titre among blood donors and to assess the decreasing incidence of COVID-19 in the department of blood bank, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand. Materials and Methods: An observational, cross-sectional study was conducted at the department of blood bank, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand over a period of 2 months and 14 days from 06 February 2021 to 20 April 2021 who donated at least one unit of blood. Results: This study recorded a greater number of male donors with B+ blood group. The anti-SARS-CoV-2 titre were mostly young adults between 18 and 31 years of age. Conclusion: Seroprevalence was high in males having blood group B+ between 18 and 32 years of age.