The recent outbreak of coronavirus infectious disease 2019 has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of an ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARS-CoV) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-CoV, COVID-19 virus exploits the angiotensinconverting enzyme 2 (ACE2) receptor to gain entry inside the cells. This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COIVD-19. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host−virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement.

No abstract

This study aims to investigate the current issue and challenges faced by the construction companies of Kabul, Afghanistan due to Covid-19 pandemic. At the same time, study also explore the possible initiatives that should be taken by the government to overcome the challenges faced by the construction companies. For this purpose, qualitative methodology was employed based on interpretivist philosophy and inductive approach. Phenomenological methodology is capitalized to achieve the study objectives. Semi structured in-depth interviews were conducted with twelve respondents from the construction companies of Kabul, Afghanistan. This study concluded that construction business operations, supply chain, revenue and funding (financing) were badly affected by the pandemic which led to unemployment and instability of construction sector. Furthermore, the study found that government can play a vital role in helping the construction business by reducing the interest rates, providing tax subsidies, reduction in the utility charges and creation of crisis fund for the construction sector. Finally, this study recommends that government should take the initiatives mention above as soon as possible before the construction sector witness a collapse.

No abstract