Objective: To study the efficacy of Progesterone supplementation for prevention of preterm birth. Study Design: Descriptive Interventional Study. Setting: Department of Obstetrics and Gynecology at Independent University Hospital, Faisalabad. Period: January 2018 to December 2020. Material & Methods: Data collected by using Non probability consecutive sampling techniques. Total 156 patients were included in study. Data was collected after informed consent, on pre designed proforma. Patient presented in 1st trimester and having previous history spontaneous preterm labour and recurrent miscarriages. We included patient presenting after 24 weeks of pregnancy and patient having threatened or actual preterm labour. Results: Among 156 patients, more than 82% of patient were delivered after 34 weeks of gestation and 18% were delivered before 34 weeks of gestation. Fetal outcome was very good in those patients who were delivered after 34 weeks of gestation with the use of Prophylactic progesterone therapy. Conclusion: Prophylactic use of progesterone helps in prolongation of pregnancy beyond 36 weeks and also help in decreasing the morbidity associated with premature delivery.

Objectives: To determine the maternal and fetal outcome in patients presented with major degree Placenta previa and to evaluate the Potential risk factors. Study Design: Descriptive Case Series study. Setting: Department of Obstetrics and Gynecology Independent University Hospital Faisalabad. Period: January 2020 to February 2021. Material & Methods: All patients with major degree previa confirmed by ultrasonography beyond 28 weeks of gestation were selected irrespective of their parity, type of placenta previa and with live or dead fetus. Results: Total 38 patients were selected with Major degree placenta previa in 1 year of duration. 47% patients were in age group 31-35 years and 65.7% patients were grand multi-para. In our study 73.6% patients were having previous scar uterus. All patients received blood transfusions and cesarean hysterectomy in 36.8% of patient’s done due to placenta previa and uncontrolled hemorrhage. Only 2 patients got bladder injuries during surgery and in one patient required hysterectomy has to be done later. Regarding neonatal outcome 47.3% neonates were active and required no resuscitation and 21% neonates expired within 48 hours. Conclusions: Now a day’s major degree placenta previa is a main obstetrical challenge associated with blood transfusion, ICU admissions and Obstetrical hysterectomy. Fetal outcome was relatively satisfactory. Maternal complications can be reduced by early diagnosis, Identification of the risk factors, correction of Anemia, Blood arrangement & Team work in Territory care hospital.