The aim of the study was to develop simple, minimally invasive method of transient multiple removal and subsequent reimplantation of abdominal and retroperitoneal organs with multisystemic neoplastic lesions, allowing subsequent reimplantation of the organ block after extracorporeal surgery.Material and Methods. Ten human cadavers of subjects who died of causes unrelated to pathology of the abdominal organs were used in this study.The anatomical experiment involved transient multiple removal of the abdominal and retroperitoneal organs with multisystemic neoplastic lesions and their subsequent reimplantation. Surgery was performed using the method developed at the Department of Operative Surgery and Topographic Anatomy of I.M. Sechenov First Moscow State Medical University (Patent RU 2601100).Results. The proposed method showed several advantages: consistency of cold perfusion in deep hypothermia of the patient, hypothermic circulatory arrest of the abdominal organs (up to 4-6 h); feasibility of insertion and subsequent removal of arterial and venous shunts, reimplantation of the abdominal organs; restoration of arterial and venous blood flow in the patient (cadaver) and preserved integrity of the transected anatomical structures.Conclusion. The proposed method of transient multiple removal and subsequent reimplantation of the abdominal and retroperitoneal organs with multisystemic neoplastic lesions provides sustained viability of the organs and can be recommended as a suitable model for further application in clinical practice. The available literature provides no description of performing multiple autotransplantation in a clinical setting. There are only a few references regarding surgical treatment of the target organ during its autotransplantation [5].The aim of the study was to develop simple, minimally invasive method of transient multiple removal and subsequent reimplantation of the abdominal and retroperitoneal organs affected by multisystemic neoplastic lesions, allowing subsequent reimplantation of the organ block after extracorporeal surgery.Materials and Methods. The method of transient multiple removal and subsequent reimplantation of the abdominal and retroperitoneal organs affected by multisystemic neoplastic lesions [6] was developed on the basis of multiple organ retrieval for transplantation [7] with due consideration of the disadvantages of the latter.Ten cadavers of the subjects who died from causes unrelated to pathology of the abdominal organs were used in this study.
Since the number of patients in need of transplantation is growing, there is much concern about retrieval, temporary preservation and subsequent implantation of various donor organs. Improper cooling of donor organs is likely to result in their injury and subsequent rejection at transplantation. To date, detailed investigation has been carried out only in relation to heat transfer process in cooling of thin renal tissue samples. The aim of the study was to develop a mathematical model of donor kidney cooling and to compare the results obtained by using it to the experimental findings. Materials and Methods. The mathematical model of donor kidney cooling has been developed. A mobile experimental installation was created to compare calculation results obtained using the model to the experimental data. Results. The developed model adequately describes the process of kidney cooling. The obtained values of porosity coefficient ξ=0.00248 and thermal conductivity coefficient λ=0.55 W/(m•K) can be used in the development of new cooling methods. The found discrepancy between the experimental and calculated results can be attributed to insufficient regard for kidney structure details in the model and influence of these details on the system of cooling liquid flow.
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