No abstract

The study included 52 patients with suspected pancreatitis who were admitted to the hospital on an emergency basis, who receive renal replacement therapy (programmed hemodialysis) in history. The control group included 50 outpatients on programmed hemodialysis. The study did not include patients with suspected pancreatitis who did not receive programmed hemodialysis. The concentration of p2-microglobulin and ferritin in the blood serum was determined in the studied groups. The most statistically high concentration of p2-microglobulin was found in the group of patients with suspected uremic pancreatitis, and the concentration of ferritin is highest in the group of patients with suspected destructive pancreatitis who received a history of renal replacement therapy (programmed hemodialysis). In the control group of outpatients receiving programmed hemodialysis procedures, there were no statistically significant fluctuations in serum concentrations of p2-microglobulin and ferritin.

Objective. To determine the blood serum 2-microglobulin and 2-macroglobulin concentration in patients undergoing renal replacement therapy (programmed hemodialysis) for the diagnosis of uremic pancreatitis and / or destructive pancreatitis. Materials and methods. The study involved 52 patients admitted to the Surgical Unit of Astrakhan "RZhD-Medicine" Hospital and City Clinical Hospital № 3. The blood serum 2-microglobulin and 2-macroglobulin concentration was analyzed in patients admitted on an emergency basis with suspicion of uremic pancreatitis and destructive pancreatitis, who receive renal replacement therapy (programmed hemodialysis). The control group included 50 outpatients undergoing renal replacement therapy (programmed hemodialysis). The study did not include patients with suspected pancreatitis who were not receiving renal replacement therapy. The period of the study is 20192021. Results. The concentration of blood serum 2-microglobulin is statistically higher than normal in all patients, who had received renal replacement therapy (programmed hemodialysis) in anamnesis. The most statistically high concentration of 2-microglobulin was revealed while studying patients with uremic pancreatitis (n = 34), and was (30.0 2.75 mg/l) compared with the blood serum concentration in patients with destructive pancreatitis (8 0.51 mg / l). The concentration of 2-macroglobulin was statistically lower in destructive pancreatitis (n = 18) and was 615 161 mg/l compared with uremic pancreatitis (980 216 mg/l). In the control group of outpatients (n = 50) receiving renal replacement therapy (programmed hemodialysis), no statistically significant blood serum concentrations of 2-microglobulin and 2-macroglobulin were found. Conclusions. A clear dependence of the concentration of 2-microglobulin and 2-macroglobulin on the severity of uremic pancreatitis and destructive pancreatitis was established. Statistically high values of 2-microglobulin concentrations were obtained in patients with uremic pancreatitis, and the 2-macroglobulin level was statistically low in destructive pancreatitis.

Objective. Determination of blood serum 2-microglobulin and lactoferrin concentration in patients on renal replacement therapy (programmed hemodialysis) for the diagnosis of uremic pseudoperitonitis and peritonitis. Materials and methods. We examined 56 patients admitted to the Surgical Department of Astrakhan Clinical Hospital RZhD-Medicine and City Clinical Hospital № 3, and studied the concentration of blood serum 2-microglobulin and lactoferrin in patients urgently hospitalized with suspicion of uremic pseudoperitonitis or peritonitis, who receive renal replacement therapy (programmed hemodialysis). The control group included 50 outpatients on renal replacement therapy (programmed hemodialysis). The study did not include patients with suspected peritonitis who did not receive renal replacement therapy (programmed hemodialysis). The period of the study is 20192021. Results. The concentration of serum 2-microglobulin is statistically higher than normal in all patients receiving renal replacement therapy (programmed hemodialysis) in anamnesis. The most statistically high concentration of 2-microglobulin was detected in patients with uremic pseudoperitonitis (n = 39), and was 30000 6680 ng/ml compared with the concentration in the blood serum among patients with peritonitis 6000 519.9 ng/ml. The concentration of lactoferrin is statistically high in peritonitis (n = 17) and was 3480 439 ng/ml compared with uremic pseudoperitonitis 1160 148 ng/ml. In the control group of outpatients (n = 50), who received renal replacement therapy (programmed hemodialysis), no statistically significant concentrations of blood serum 2-microglobulin and lactoferrin were detected. Conclusions. A clear dependence of 2-microglobulin and lactoferrin concentrations on the severity of uremic pseudoperitonitis and peritonitis was established. Statistically high values of 2-microglobulin concentration were obtained in patients with uremic pseudoperitonitis, and the level of lactoferrin was statistically high in peritonitis.