In patients with acute kidney injury (AKI), serum creatinine level does not increase until moderate to severe reduction in glomerular filtration rate (GFR) occurs. Thus its use for estimating GFR in early AKI delays detection of kidney damage and making important therapeutic decisions. Moreover, serum cystatin C is not affected by gender, age, race, and muscle mass and also does not suffer from lag period for its rise in early AKI. We studied 200 healthy subjects and 130 AKI patients over a period of 2 years at a tertiary care hospital. Serum creatinine and serum cystatin C were studied and analyzed in relevance to early AKI. We found that 56.2% of patients of AKI group had normal levels of serum creatinine in early phase, while all patients had elevated serum cystatin C at same time. Multiple logistic regression analysis revealed cystatin C-based GFR reflecting decline in GFR with worsening AKI in better than creatinine-based GFR. Serum cystatin C is a better marker of renal function in early stages of AKI and is less affected by age, gender, muscle mass, and ethnicity. Its use helps in early therapeutic intervention and possibly favorable outcome.

In the present work, elasto-plastic creep crack growth simulations are performed using continuum damage mechanics and extended finite element method. Liu–Murakami creep damage model and explicit time integration scheme are used to evaluate the creep strain and damage variable for various materials at different temperatures. Compact tension and C-shaped tension specimens are selected for the simulation of crack growth analysis. For damage evaluation, both local and nonlocal approaches are employed. The accuracy of the extended finite element method solutions is checked by comparing with experimental results and finite element solutions. These results show that the extended finite element method requires a much coarser mesh to effectively model crack propagation. It is also shown that mesh independent results can be achieved by using nonlocal implementation.

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This paper investigates the static bending and free vibration analysis of functionally graded piezoelectric material beam under electromechanical loading. The effective material properties of functionally graded piezoelectric material beam are assumed to vary continuously through the thickness direction and are graded according to sigmoid law distribution. Both multi-layered and monomorph models have been considered in the present work. A two-dimensional finite element analysis has been performed using COMSOL Multiphysics Õ (version 4.2) software. The accuracy of the method was validated by comparing the results with the previous published work. The results presented in the paper shall be useful in the design of functionally graded piezoelectric material beam.

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