Abstract-Reactive Oxygen species (ROS) are believed to be responsible for pathogenesis of various diseases affecting tissues and the main organ, the Liver. Hence, in the present study, the extent of Lipid Peroxidation (LPO) and ROS elimination and its defense mechanisms by the enzymic & non enzymic antioxidants in liver & serum was investigated. Hepatoxicity was manifested by significantly decreased (p<0.05) levels in the activities of the enzymic antioxidants such as Superoxide dismutase (SOD) Catalase (CAT), Glutathione peroxidase and the non enzymic antioxidants such as glutathione & Vitamin C in rats induced hepatic damage by ethanol Simultaneous administration of the leaf extract Mimosa pudica along with the toxin ethanol in rats showed a considerable protection against the toxin induced oxidative stress and liver damage as evidence by a significant increase (p<0.05) in antioxidant activities. The study reveals that the co administration of Mimosa pudica aqueous extract significantly lowered the level of lipid peroxidation in alcohol fed mice.