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Summary. The data presented in this paper show that mice may be immunised against re-infection with Nematospiroides duhius by giving live third-stage larvae orally, intravenously, intraperitoneally or subcutaneously. Immunity is directed not against the adult worm but against the third-stage larvae following their penetration of the wall of the intestine.

Summary. The results of the present study show that peritoneal exudate cells from mice immune to infection with Nematospiroides dubius are able in vitro to damage the third stage infective larvae as measured by a loss in infectivity. The ability of these cells to function in the absence of specific antibody seems to be related to the presence of trypsin labile factors on their surfaces. Lymphocytes from immune mice are also able to damage the larvae. The suggestion is made that 'activated' macrophages may play an important role in immunity to this infection.

SummaryData presented show that in vivo peritoneal exudate cells of mice immune to infection with Nematospiroides dubius are capable of damaging the infective third stage larvae of this parasite. Experiments utilising chambers closed with membranes of different pore size and implanted in the peritoneal cavity indicated that damage requires intimate contact between the cells and larvae. Examination of the cells in contact with the larvae revealed that these cells were predominantly macrophages. The fact that peritoneal exudate cells of normal mice are unable to damage the third stage larvae even in the presence of serum from immune animals, although binding to the larvae, suggest that cells of immune mice have been “activated”.