The word diabetes describes a category of metabolic disorders characterised and defined by hyperglycemia in the absence of therapy. Type 1 & 2 diabetes mellitus are two main types. It is now widely accepted that failure or loss of pancreatic β (beta) cells is the underlying common feature of all types of diabetes. In this study, male Wistar albino rats of approximate weighing 180-250 g were used. Compound 2-(4-[(2-hydroxy benzyl) amino]-phenyl amino-methyl)-phenol derivatives were used to assess the anti-diabetic activity. Derivatives such as hydroxyl amino, acetyl keto, and hydro benzophenone groups are derivatives and are further studied for the screening of anti-diabetic activity. Diabetes was produced by intraperitoneal administration of Alloxan in male Wistar albino rats. Rats were divided into 12 groups of six in each group. The outcomes of the study reveal compound C - 60 mg/kg shows significance in decreasing the blood sugar level when compared to control. A significant effect on blood sugar levels was shown by glibenclamide 20 mg/kg. The study concludes that Biological activities of 2-(4- [(2-hydroxy benzyl) amino]-phenyl amino-methyl)-phenol derivatives of compound C - 60 mg/kg has high blood sugar-lowering activity.

Diabetes Mellitus is known as a syndrome, a collection of disorders with high blood glucose level & glucose intolerance as its feature, either because of insulin deficiency or insulin impairment or both. Diabetes Mellitus, based on insulin, is broadly classified into two types. Type one indicates the distraction of pancreatic β - cells that leads to diabetes mellitus, in which insulin is necessary to prevent ketoacidosis, coma, death. Type two diabetes is characterized by disorders of insulin resistance & secretion. Male Wistar albino rats with an average weight of 180-250 g were used in this study. With a 12 hours’ light and dark period, they were kept under normal conditions (room temperature 24-27oC and humidity 60-65 %). The free access of drinking water & pellet diet to male Wistar albino rats was allowed, as per the CPCSEA guidelines. Anti-diabetic activity of Compound 2-(4- [(2-hydroxyacetyl benzyl) ketoamino]-phenyl amino-methyl)- hydrobenzophenon, male Wistar albino rats were divided into four different groups. 1ml of blood samples were collected directly into anticoagulant bottles from the tail vein & later plasma was collected after centrifugation. Blood sugar levels were determined by spectrophotometer. There was a significant decrease in blood sugar levels in Alloxan + Glibenclamide and Alloxan + Compound groups on compared to control. The present self-funded study concludes that antidiabetic activity of 2-(4- [(2-hydroxyacetyl benzyl) ketoamino]-phenyl amino-methyl)- hydrobenzophenon in Alloxan induced diabetic rats significantly shows decreed blood sugar levels when compared to the control group.