A new method has been developed for ttw svntlwsis of 2-phenylproline and its derivatives by intramolecular cw'lization of the corresponding derivatives of N-(3-cldoro-or l-o.to-3-chloropropyl)-c~-phenylglycine under phase transfer catalysis conditions.

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Acylation of the silyl esters of amino acids, specifically glycine, b-alanine, sarcosine, glycylglycine, and 6-aminopenicillanic acid, with 1-phenyl-3-oxo-2-methyl-1-cyclopentane carboxylic acid chloride yielded new analogs of the known antitumor antibiotic sarcomycin. The resulting compounds had high levels of antitumor activity.

A series of new semisynthetic penicillins and cephalosporins containing structural fragments of the well-known antitumor antibiotic sarcomycin have been synthesized and their antitumor and antibacterial properties have been studied. The synthesized compounds showed substantial antitumor and antibacterial activities.

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