Suprunchuk V. Ultrasonic-treated fucoidan as a promising therapeutic agent [published online as ahead of print on December 15, 2021].

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Ultrasonic exposure can be used for depolymerization of brown algae polysaccharides. However, its effectiveness depends on several factors, including cavitation activity in the treatment medium. Therefore, the purpose of the work was to determine the cavitation activity and the effectiveness of the ultrasonic exposure to fucoidan in order to optimize the processing processes of polysaccharide from brown algae. A change in cavitation activity was revealed depending on the composition of the processing environment, as well as on the intensity of ultrasonic exposure with a constant frequency of the ultrasonic wave. Similar dynamics of change of cavitation activity were established at the intensity of ultrasonic treatment of 100 and 133 W/cm2 with amplification of electric signal at the increase of ultrasound intensity. The use of SDS in the processing medium led to an increase in cavitation activity to 14.9±0.47 mV. Treatment of the fucoidan solution for 40 minutes under various conditions allowed to obtain fractions with a change in the average hydrodynamic particle diameter from 113 nm (100 W/cm2) to 85 nm (200 W/cm2) and 124 nm (SDS).