SUMMARY Two accessions of the wild species Helianthus annuus L., GT-E-112 and GT-E-126, carried genes for resistance to Plasmopara helianthi Novot., Phomopsis helianthi Munt.-Cvet. et al. and Orobanche cumana Wallr. The material produced by interspecific hybridization with susceptible cultivated sunflower showed resistance to the three pathogens. Some progenies were resistant to two pathogens simultaneously. Self pollination helped to increase the percentage of resistance up to 100%. Accessions GT-E-112 and GT-E-126 of the wild species Helianthus annuus could be successfully used as donors for resistance to Plasmopara helianthi, Phomopsis helianthi and Orobanche cumana.