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Background: There is little information on the possible impact of drugs used in the treatment of multi-drug resistant tuberculosis (MDR-TB) on glycaemic levels. This study therefore assessed changes in glycated haemoglobin levels in patients with MDR-TB. Materials and Methods:This longitudinal study involved 21 MDR-TB patients who were followed up for 6 months. Glycated haemoglobin (HbA1c) level of each patient was determined before the commencement of MDR-TB drug regimen and at 2, 4 and 6 months post treatment as part of a study which investigated them every 2 months. Differences in means were assessed using the paired Student's t-test and statistical significance was set at P<0.05. Results:A patient had undiagnosed diabetes mellitus (DM) with an HbA1c value of 6.5% and died before the second month sample collection; another patient became critically ill; therefore, 19 patients completed the study. Before the commencement of MDR-TB therapy, two patients had pre-diabetes with HbA1c values of 6.0% and 5.8% while the HbA1c values of the remaining patients were less than 5.7%. There was a significant reduction in the mean HbA1c level at 2 months post therapy compared with the baseline. However, the HbA1c levels increased slightly after the 2 nd month of therapy but no significant change was observed in the HbA1c levels at 4 and 6 months of MDR-TB therapy compared with baseline.Conclusion: Diabetes mellitus is not common among Nigerians with MDR-TB and MDR-TB drug regimen might have an acute effect on glycaemic changes in patients with MDR-TB. : 08075010718 TITRE COURANT: L'HÉMOGLOBINE GLYQUÉE CHEZ LES PATIENTS ATTEINTS DE TUBERCULOSE MDR INFECTION ABSTRAIT Résumé Contexte: Il y a peu d'information sur l'impact possible des medicaments utilisés dans le traitement de la tuberculose multirésistante (TB-MR) sur les niveaux glycémique. Cette étude, par conséquent, évalué les changements dans les niveaux d'hémoglobine glycosylée chez les patients atteints de tuberculose multirésistante. Matériels et méthodes: Cette etude longitudinale a concerné 21 MDR-TB patients qui ont été suivis pendant 6 mois. L'hémoglobine glyquée (HbA1c) niveau de chaque patient a été determine avant l'entrée en vigueur de la MDR-TB Traitement medicamenteux et à 2, 4 et 6 mois après le traitement dans le cadre d'une étude qui a enquêté sur tous les 2 mois. Les differences dans les moyens ont été évalués à l'aide de la paire de test t deStudent et la signification statistique a été fixé à P<0,05. Résultats: Un patient avait non diagnostiqué le diabète sucré (DS) avec une valeur d'HbA1c de 6,5% et est décédé avant le deuxième mois sample collection; un autre patient est devenu gravement malade; par conséquent, 19 patients ont terminé l'étude. Avant le début de la MDR-TB thérapie, deux patients avaien tpré-diabète avec les valeurs de l'HbA1c de 6,0 % et 5,8 % alors que le taux d'HbA1c des autres patients étaient inférieures à 5,7 %. Il y avai tune reduction significative de la moyenne de l'HbA1c 2 mois après traitement par rapport à la baseline. Concl...

Tuberculosis (TB) is primarily a lung disease (pulmonary tuberculosis, PTB) but the bacilli can also develop in other places in the body, such as the bones, liver and kidney as extra pulmonary tuberculosis. Hepatic and renal involvements in PTB patients are mostly secondary to TB chemotherapy that is potentially hepato-and nephro-toxic. In this study, the biochemical parameters that indicate renal and hepatic involvements were analyzed in the sera of MDR-TB patients with and without HIV co-infection prior to commencement of chemotherapy. Out of 115 MDR-TB patients (76 males and 39 females) recruited for the study, 22 patients (11 males and 11 females) were co-infected with HIV. Serum levels of sodium (Na + ), potassium (K + ), chloride (Cl -) were analyzed using Easylite (ISE technology), bicarbonate (HCO3 -) was analysed using back titration method, urea and creatinine were determined spectrophotometrically using Diacetlymonoxime (DAM) method and Jaffe's alkaline picrate method respectively. Total and direct bilirubin, serum glutamate oxaloacetate transferase (SGOT), serum glutamate pyruvate transferase (SGPT), alkaine phosphatase(ALP), total protein (TP) and albumin (Alb) were determined using Hitachi 912 autoanalyzer. There were no statistical significant differences in the renal and hepatic parameters of TB patients with HIV compared with TB patients without HIV. However, significantly higher proportions (89%) of MDR-TB patients had their SGOT within reference range. The mean values indicate that HIV infection did not significantly alter renal and hepatic profiles in MDR-TB patients prior to treatment.

Background: Kidney involvement in coronavirus disease 2019 (COVID-19) pathology has been supported by high frequency of angiotensin-converting enzyme 2 (ACE2) expression on renal cells and reports of acute kidney injury. However, the association between host viral load and kidney function is not clear. Aim: In this study, plasma levels of renal markers (urea nitrogen, creatinine, and estimated glomerular filtration rate (eGFR)) and electrolytes (sodium, potassium, chlorine, and bicarbonate) were assessed in relation to SARS-CoV-2 viral load of COVID-19 patients. Patients and Methods: This cross-sectional study involved 144 consenting COVID-19 patients admitted to the Ogun state COVID-19 isolation center between May and December 2020. All participants presented with mild respiratory symptoms and did not require ICU admission or ventilation support. Data included reverse transcriptase polymerase chain reaction (RT-PCR) cycle threshold (C T ) value, blood urea nitrogen (BUN), creatinine, sodium, potassium, chlorine, bicarbonate measurements, and glomerular filtration rate. Reference intervals were used as comparators, and multiple linear regression model was fitted. Statistical significance was set at P < 0.05. Results: BUN level and creatinine were elevated in 4 (2.8%) and 42 (29.2%) patients, respectively, with lowered eGFR observed in 37 (25.7%) patients. Hyponatremia and hypokalemia were observed in 35 (24.3%) and 21 (14.6%) patients, respectively, while hypochloremia was observed in 21 (14.6%) patients. Lowered bicarbonate was observed in 29 (20.1%) patients. Linear regression showed statistically significant association (R2 = 0.340, P = 0.032) between RT-PCR C T value and eGFR (b = 0.006, P = 0.017) as well as HCO3 (b = -0.262, P = 0.036). Conclusion: COVID-19 patients with mild respiratory symptoms exhibited renal abnormalities, electrolytes, and acid-base imbalances which were partly associated with SARS-CoV-2 viral load.