The use of ovarian stimulation induces changes in the follicular fluid and in CC GE that may affect immune processes, meiosis and ovulation pathways. Although these differences do not seem to relate to early-stage embryo morphology, the implications of some of the molecules, especially ALDH1A2, CTSL and ZNF33B at the CC level, deserve to be addressed in future studies.

The present project has been supported by the R+D programme from the Generalitat Valenciana (Regional Valencian Government) IMPIVA MIDTF/2010/95. The authors have no conflict of interest to declare.

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FISH component (p¼0.003). Female age approached significance in both models; each year increased the risk of SAB by 1.2% (p¼0.081). Sperm disomy, male age, female reproductive factors, semen volume, sperm density, and sperm motility did not predict SABs (p>0.05). Abnormal FISH testing did not predict IF (p¼0.259). The overall pregnancy rate in men with abnormal sperm FISH was 0.95% using IUI, 10.2% using IVF, 14.8% using IVF/ICSI, and 50% when preimplantation genetic screening (PGS) was added to IVF. CONCLUSIONS: The incidence of aneuploid abnormalities of chromosomes 13, 18, 21, and the sex chromosomes on sperm FISH testing predicts SABs. Couples with abnormal sperm FISH results should be counseled regarding the potential negative pregnancy outcomes, and IVF with PGS discussed.