Benzamide antipsychotics such as amisulpride are dosed as racemates though efficacy is assumed to be mediated through S enantiomer binding to D 2 receptors. At prescribed doses, the benzamides likely display polypharmacy since brain exposure should be sufficient to engage the 5-HT 7 receptors, as well. Curiously, the studies herein reveal that racemic dosing is required to engage both targets since the D 2 receptor has an almost 40-fold selectivity for the S enantiomer, while the 5-HT 7 receptor has greater than 50-fold preference for the R enantiomer.

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