In the presented review of the current literature a lot of information about differente diagnostic approaches for patients management with a syndrome of noncardiac chest pain were system- atized and generalized.These patients have a diverse set of disease that requires the physician applying a wide range of ad- ditional surveys. In General, doctors need to exclude heart disease in patients who were treated with chest pain. If chest pain is noncardiac, then empirical treatment for gastro-intestinal reasons and the cor- responding assessment of psychogenic causes of chest pain are important for the symptomatology of pa- tients. In particular, primary care physicians should consider - besides the cardiac causes as a possible causes of thoracalgia - possible mental disorders, impaired motility of the upper gastrointestinal tract, problems with the thoracic spine - as a possible causes of thoracalgia. It would be beter to find out the rea- sons of thoracalgia with all available diagnostic tools and then - choose and assign appropriate adequate etiotropic therapy for most effectively cupping the patient's symptoms and reducing health care costs.