Les résultats de l’étude portant sur la pureté radiochimique du produit 197Hg- CM sont présentés. On a étudié aussi la distribution de 197Hg-CM dans les organes des animaux expérimentaux. Le maximum de la radioactivité a été trouvée dans les reins au bout de deux heures après l’injection. On a constaté que la 197Hg-CM a l’état hydroxy a été excretée par les urines. La concentration de cet état chimique dans les urines augmente avec le temps de retention du produit dans l’organisme.

The results of analysis of 99mTc-Pyrophosphate (99mPyP), taken as a representative of the group of compounds having an organic P-O-P bond, and of the three diphosphonate compounds: methylene diphosphonate (MDP), 2,3-dicarboxy propane diphosphonate (DPD) and ethane-1-hydroxy-1, 1-diphosphonate (EHDP), which differ in their chemical structure, are shown. Also, some physicochemical parameters such as chloroform-water apparent partition coefficient, the osmotic pressure and pH values in final preparations were studied. The radiochemical purity of these radiopharmaceuticals was determined by the two methods: Sephadex chromatography for separation of 99mTc-hydrolysate and TLC on silica gel with 85% methanol for the determination of free 99mTcO-4. The yield of labelling for both methods was over 90%. Also, pharmacokinetic parameters such as binding to the plasma proteins and to erythrocytes were determined. 99mTc-PyP binding to plasma proteins was higher than the binding of diphosphonate compounds. The quantitative distribution of preparations was determined in experimental animals.

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