Morphological changes in an experimental purulent wound in a rat model is studied for application of surgical gauze with immobilized enzymes: trypsin, lysozyme, coUitin, or co-immobilized trypsin and lysozyme. Comparison of the times of wound cleansing and healing shows that immobilized enzymes are more effective than native preparations, and the therapeutic effect of gauze with the enzyme complex is higher than that of gauze with individually immobilized enzymes. Morphological studies confirm that immobilized trypsin-lysozyme complex and coilitin are the most efficient in hastening and potentiating reparative processes in a purulent wound.