Because of the demonstration of a genetic linkage between glucokinase and Type II diabetes, and the central role of glucokinase on glucose metabolism, we studied glucokinase activity in the liver of patients with and without Type II diabetes. Glucokinase activity was decreased by about 50% in obese subjects with diabetes (n = 12) compared with (p < 0.01) lean controls (n = 9) and (p < 0.05) obese controls (n = 10). There was no difference between lean and obese controls. Fifty percent of subjects with diabetes had lower liver glucokinase activity than the lowest value of the controls. These data further support the important role that glucokinase plays in the pathogenesis of Type II diabetes.

Obesity is an increasing health concern in India in recent times, mainly due to sedentary lifestyle and irregular dietary pattern which leads to metabolic syndrome. Materials and Methods: In our Diacare, Diabetes Care and Hormone Clinic, study of a 30 years, Female with Body mass index (BMI) of 34.3kg/m 2 and waist hip ratio (WHR) of 1.01 was done. Results: The patient was diagnosed with Syndrome Z and was followed up for one year with lifestyle modifications in dietary and regular physical exercise. Metformin and glucagon-like peptide-1 receptor agonist (GLP-1RA) was prescribed for 24weeks and 12 weeks respectively. By the end of one year gradual improvement in her BMI, WHR, and reversal of diabetes was achieved. Conclusion: It has been concluded from this case study that diabesity, which is a growing epidemic (obesity and type 2 diabetes) can be treated with proper dietary modifications, regular exercise and therapy. Reversal of diabetes can be achieved. Obesity is one of the main concern for many high risk diseases in our country and should be focused upon and treated as one of the major illnesses.