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The purpose of the study is a comparative analysis of some indicators of physical development and physical fitness of university students of various physical education groups before and after the restrictions of COVID-19. The article presents the experience of monitoring the physical development of higher school students by the Laboratory of Sports and Tourism (LS&T) of the Institute of Physical Culture of Sports and Tourism (IFKSiT) of the Siberian Federal University (SFU).The indicators of physical development and physical fitness of students of 1–3 courses, boys and girls aged 17–22 years of physical education groups: aerobics, basketball and special medical group (SMG) of various institutes of SFU are represented, the analysis shows that these indicators in the groups under study during the predominance of distance learning are insignificantly reduced. The most reduced indicator is the relative strength indicator. The lowest indicators of physical development and physical fitness for all the considered parameters are characteristic of SMG students. The least reduced indicators of physical development and physical fitness were characteristic of the representatives of the aerobics groups, while the flexibility indicator was improved. The current unfavorable epidemiological situation has confirmed the need for the development of various systems for monitoring indicators of physical and functional conditions, physical development, health and physical fitness for higher education, both in the context of the implementation of the subject of physical culture in the educational process and correction of developmental influences during classes, and in the formation of a health-preserving environment of educational institutions.

The substitutive enzymatic therapy is vital in cystic fibrosis patients with pancreatic insufficiency. Usually patients are given enzymes at every meal. If it is necessary to replace one enzymatic remedy to another, the replacement should be done gradually (for 12-14 days). A comparative study of encapsulated enzyme preparations Creon 10 000 IU/25 000 IU and Pangrol 10 000 IU/25 000 IU safety, efficacy and tolerability was done in 20 patients with cystic fibrosis at the age of 11 months - 16 years. 13 people have got the doses in the calculation of the lipase up to 100 TU; and more than 100 TU - 7 people. Different drug doses effectiveness was determined according to faeces parameters and coprogram indicators. Numerical evaluation of the clinical efficacy and tolerability of both drugs was conducted through a questionnaire survey of patients and specialists. All patients completed the study. The effectiveness of the treatment according to coprogram was the same in both groups. In most cases, the process of transferring patients from Creon on Pangrol passed without the appearance of negative symptoms. It has been shown that encapsulated, mini-tablet pancreatin Pangrol well tolerated by patients. This allowed to 60 % of patients with cystic fibrosis change the treatment from Creon on Pangrol. Adverse events (10 %), detected in the process of transferring patients from one drug to another, were rare and short-term. The majority of physicians and patients prefer to continue therapy with Creon, according to their previous successful experience. Step-by-step scheme of replacing one enzymatic remedy on another is shown in this paper.

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