According to the Regulation (EC) of the European Parliament and of the Council of the European Union No. 852/2004 and No. 853/2004 “Оn the hygiene of foodstuffs” dated April 29, 2004, Ukrainian producers of both pasteurized and raw cow's milk should be guided by regulatory acts, in particular, DSTU 2661:2010 “Drinkable cow’s milk. General technical conditions” and DSTU 3662:2015 “Cow’s milk-raw. Technical conditions”, which are harmonized to the requirements of the EU, and are regulating the safety and quality of milk for adhering to the proper sanitary and hygienic requirements of their primary production and industrial processing, and use modern, effective developed and tested rapid control methods of milk and dairy products for their falsification. Taking into account that today the falsification of milk as pasteurized and raw is not a rare occurrence, it is especially important to develop and introduce new express methods for the detection of various chemical reagents in dairy products that impair their quality and can affect their safety. We have developed simple, effective, reliable express methods: the determination of the number of somatic cells in milk by using Reagent N; detection of milk falsification by sodium bicarbonate using an alcoholic solution of bromocresol green with a mass concentration of 0.01%; as well as by alkaline detergents using an alcoholic solution of bromotymol blue with a mass concentration of 0.02%. Determination of the number of somatic cells in cow's milk by express method using Reagent N gave a 99.8% confidence in qualitative indices. The colour and consistency of milk varies, depending on the number of somatic cells – from liquid with bright orange to the formation of a jelly-like clay dark-raspberry colour which is easily removed from the hole of the dairy plate. An express method for detecting falsification of milk by sodium bicarbonate has the following advantages over existing commonly used methods: the results are specific, with a reliable qualitative index of 99.9%, consisting in changing the colour of the circular layer of milk, depending on the amount of baking soda added to it. In the absence of sodium hydro-carbonate, the colour of the circular layer of milk has a dark green colour, and if it is present, it acquires a dark blue-green colour of varying intensity. The express method of the milk falsification determining by alkaline detergents is easy to implement, and its results give specific qualitative indicators of 99.9%. Depending on the amount of alkaline detergents added to the container with milk (up to 1, 5, 10%), the milk acquires a blue colour varying intensity.

We presented the effect of prebiotic "Bio-active" on preservation, increase of the body weight, the microflora composition in the distal small intestine, histological examination of the intestinal wall and liver of rabbits gray giant breed 45 days aged. Prebiotic "Bio-active" contains products of metabolism of lactic acid bacteria Lactobacillus bulgaricus delbrueckii adsorbed on zeolite. Our results proved the safety of this prebiotic for the rabbits. Optimal scheme for oral administration of the prebiotic was 2.0 g per 1 kg of body weight for 30 days. Such a course provided 95% of animal preservation and increase in the weight gain of the experimental animals, an average of 43.1% compared with the non-treated rabbits. In scarifies of distal intestine in 20% of animals that received the prebiotic and in 100% of those who did not receive it, Bacteria of Proteus genus have been detected. After the course of prebiotic we registered an increased number of Enterobacteriaceae (4.5–6.0 × 108 CFU) and Bifidobacteria (8 × 107–108 CFU) in rabbits’ intestines. We also mentioned the enhanced gram-positive/gram-negative ratio with a predominance of gram-positive (1:1.17 against 1:2.9 in control group). In case of prebiotic usage, the stimulation of goblet cells’ development was determined in the small intestine walls. Almost 100% of rabbits, who did not receive the prebiotic, had dystrophic changes in hepatocytes (74.5 % of the animals had fatty hepato-dystrophy and 25 % had protein granular dystrophy). We registered that only 25% of the animals had fatty hepato-dystrophy and 15% had protein granular dystrophy among those, which received the preparation.

The rapid development of poultry farming requires increasing requirements for the safety and quality of products. This is especially true for broiler chickens, turkeys and meat production. Over the past decade, research by many scientists has shown that fundamental knowledge of the conditions of interaction of the microorganism with the microflora that inhabits biotopes and the creation and widespread introduction into practice of biological products from living or lyophilized microbial cultures – probiotics – is very important. Bacterial preparations based on living microbial cultures – probiotics – have become widespread in the technological process of growing poultry in most countries of the world, including in Ukraine. The microorganisms that make up the probiotic are representative of the normal gut flora; have high antagonistic properties against opportunistic and pathogenic microflora, even those that are insensitive to many antibiotics; have the ability to activate macrophages, ie to influence the intensity of phagocytosis; have the ability to enhance the induction of interferon, ie to influence the increase of factors of natural resistance of animals; to influence the regulation of metabolism in the body of animals, vitamin balance, intestinal digestion; have the ability to produce biologically active substances. To date, studies in the field of bacteriotherapy and prevention of various pathological conditions in animals and poultry associated with disorders of the composition of the normal gut flora are quite relevant. However, in spite of the positive characteristics that pay tribute to probiotic drugs, there are still three areas of concern for improving such drugs in order to achieve their effectiveness in use. First, the microorganisms that make up the probiotic, to a greater or lesser extent, have poor patency through the upper divisions of the digestive canal due to the action of gastric juice and enzymes on them, and therefore do not reach the thick compartment in the amount required to provide required effect. Secondly, if a small number of microorganisms in the composition of the probiotic and has reached the large intestine – it can get bad in the already competitive environment of pathogenic and pathogenic microorganisms already formed during this period. Third, in addition, the use of probiotics inhabits the thick intestine only by the microflora that is part of it and does not reproduce the diversity of its own microflora. The main advantages of probiotics over chemotherapeutic drugs and anti-tibiotics are that they are harmless to the body of the animal and are environmentally friendly. Due to the great attention to probiotics as environmentally friendly preparations, there is now an increase in the study of biological properties and selection of bacterial strains, the most promising in the probiotic respect. This is the direction of selection of strains specific for the intestinal biocenosis of a particular animal and poultry species, which have high colonization and antagonistic properties. Thus, nowadays, in poultry farming, it is impossible to completely abandon preventive vaccinations, disinfection, use of antibiotics, anthelmintics, coccidiostats and other chemotherapeutic drugs. After their use, the need for enriched diet of pro-and prebiotics increases many times over. This is justified by the need to improve the normal gut microbiota, which, in the first place, leads to increased nutrient uptake of feed and, as a consequence, to improve the nutritional and biological value of poultry products. However, in the current scientific literature, researchers have not sufficiently described the characteristics of the impact on the body of animals, including birds, the above nutraceuticals, also did not determine the quality and safety of slaughter products, did not substantiate their sanitary evaluation. Therefore, the development of new biotic drugs, especially domestic in time.

Is an acute problem with unstuffy cient regulation of hazardous components disinfectants and regulations of the European Union. This makes the development of methodological approaches to rapid normalization of disinfectants and the need to prevent their harmful effects on human health during the application according to the purpose. Ensuring the deployment procedure of state sanitary and epidemiological expertise disinfectants to scientifically based risk analysis. Remains topical scientific substantiation of monitoring programs for sensitivity to infectious agents and disinfectants containing active substances in the environment. "Geocid"a liquid concentrate transparent, light-yellow foam when shaking, has little odor, soluble in water. Working solutions anticorrosion and do not damage the painted surface of building structures, plastic and fabric.

Ukraine's food security is due to the production of a sufficient number of high-quality, environmentally friendly, high-quality food products of animal origin, including poultry products. The purpose and objectives of the study. To analyze the slaughter condition, safety, and quality of slaughter products of meat turkeys in the direction of productivity when using the prebiotic drug actigen. The object of study was turkeys of the BIG-6 breed. The prebiotic Actigen was added to the essential diet of turkeys in the following doses: from the 1st to the 21st day: 0.4; 0.8 and 1 g/kg of feed; from the 22nd to the 42nd day: 0.4; 0.6 and 0.8 g/kg of feed; from the 42nd to the 120th day: 0.2; 0.4 and 0.7 g/kg of feed. Mixing prebiotics with compound feed was performed with a feed mixer on the farm for compound feed production. The bird had free access to food and water throughout the fattening. According to DSTU 3143:2013, carcasses of broiler turkeys of experimental groups belong to the first category of fattening. The macrostructural characteristics of the organs of broiler turkeys in the experimental groups correspond to the age norm of the bird. Organomacroscopic characteristics of slaughter products of broiler turkeys of all experimental groups do not differ significantly. When determining the organoleptic characteristics of broiler turkey meat after using the prebiotic Actigen, it was established that Volodar LLC, Kyiv region, sells quality products that meet the requirements of the current National Standard. In the study of microbiological and microscopic indicators of broiler turkey meat after the use of the prebiotic Actigen, it was found that the microbiological indicators of MAFANM content in broiler turkey meat of Volodar LLC of the experimental group were 2.12 ± 0.25 × 103 and control groups 2.98 ± 1.07 × 103 according to the norms 1×106 CFU/g – fresh turkey, i.e., met the requirements of the current National Standard. It was found that the broiler turkeys' meat after using the prebiotic Actigen had a higher relative biological value – 100.0 %, compared with the control group of 95.0 % (P < 0.05). The number of Tetrahymena pyriformis cells grown on a nutrient medium with broiler turkey meat after three hours of incubation in the experimental group was 100.0 ± 5.3 – due only to motile cell forms. A similar trend remained after six hours of incubation. Infusoria had the shape of a regular shoe; they are mobile. Therefore, no adverse effect of samples of the meat of turkey broilers of Volodar LLC on the morphophysiological parameters of ciliates of Tetrahymena pyriformis was found, which indicates that the studied meat of the experimental groups is not toxic.