T he features of the organization information support for business p rocesses on the typical virtual machine-building enterprise (VME) with a multi-nomenclature nature of production in t he framework of Industrial 4.0 were considered. It has been established that in accordance with the concept of Industry 4.0, namely with the individualization of production and consumption, a modern virtual machine-building enterprise must adapt to the production of goods in small batches, moreover in a large assortment and with frequent change of nomenclature in a wide range. It is shown tha t under these conditions, the effectiveness of the implementation of production processes directly depends on the effectiveness of information support at all stages of the product life cycle (PLC). A methodology is proposed for evaluating the effectiveness of information support for PLC processes in the conditions of multi-nomenclature production of a virtual engineering enterprise. The methodological basic concepts are web-mining and multi-agent technology. A comparative analysis of the activities of a typical VME was carried out, which showed that the introduction of information support tools increased the efficiency of VME business processes.